What is a maic?

What is a maic?

Matching-adjusted indirect comparisons (MAICs) use IPD from trials of one treatment to match baseline summary statistics reported from trials of another treatment. After matching, by using an approach similar to propensity score weighting, treatment outcomes are compared across balanced trial populations.

Who were the first Native Americans in Minnesota?

The Dakota and Ojibwe were Minnesota’s first peoples, and their stories shared at the sites below are vital to understanding our history.

What is a matching-adjusted indirect comparison?

Matching-adjusted indirect comparisons (MAICs) are a form of population-adjusted ITC that attempt to reduce bias in treatment comparisons by matching patient-level data from the clinical trials of one treatment to aggregate data reported for comparator trials [17].

What is an indirect treatment comparison?

indirect comparison? treatments that have not been directly compared with each other in a head-to-head trial. It is often used when there is no evidence or insufficient evidence from head- to-head trials, or when more than two treatments are of interest.

How does a maic work?

The method works by making use of individual patient level data (IPD) for one study and adjusting that population to match summary baseline characteristics reported from a published study. Treatment-specific outcomes can then be compared across balanced populations.

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What is an unadjusted comparison?

unadjusted indirect comparison is defined as the nave use of single study arms to combine study data as if coming from a single large trial. A summary effect is computed for all study arms involving intervention A and compared to a summary effect for all study arms in- cluding intervention B.

What is the largest tribe in Minnesota?

The White Earth Band is the largest, which had more than 19,000 members. According to the 2010 US Census, the Leech Lake Band had 10,660 residents living on its reservation, the most of any single reservation in the state. Notably, the Red Lake Band of Chippewa is not part of the Minnesota Chippewa Tribe.

What does Minnesota mean in Indian?

sky-tinted waters The name Minnesota comes from the Dakota (Sioux) words mnisota meaning sky-tinted waters or sky-blue waters. There are numerous Indian origin place names throughout the state, many beginning with mni or minne meaning water. …

What are the two largest Indian reservations in MN?

Two major Native American tribesthe Dakota (or Sioux) and the Ojibwa (Anishinabe or Chippewa)lived in the area that is now Minnesota.

What is simulated treatment comparison?

There is, therefore, a need for alternative techniques, such as Simulated Treatment Comparisons (STCs). This technique is designed to derive comparisons between treatments after adjustment for differences between the populations of the two studies.

What is network meta analysis?

Network meta-analysis, in the context of a systematic review, is a meta-analysis in which multiple treatments (that is, three or more) are being compared using both direct comparisons of interventions within randomized controlled trials and indirect comparisons across trials based on a common comparator.

What is a indirect comparison called?

A simile is a figure of speech that compares two different things, usually by using the words ‘like’ or ‘as’. … Metaphors use indirect comparisons, without the words ‘like’ or ‘as’.

What does indirect comparison mean?

Indirect comparison refers to a comparison of different healthcare interventions using data from separate studies, in contrast to a direct comparison within randomised controlled trials. Indirect comparison is often used because of a lack of, or insufficient, evidence from head-to-head comparative trials.

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What is an example of an indirect comparison?

For example, consider a comparison of two drugs, A and B. Although studies comparing A and B may be unavailable, studies may have compared A to placebo and B to placebo. This makes it possible to indirectly compare the effect of A and B.

How do you match adjusted indirect comparison?

  1. Step 1: Compare the characteristics of the trial to be weighted against the target population. …
  2. Step 2: Calculate and check the MAIC weights. …
  3. Step 3: Check the balance of the weighted trials. …
  4. Step 4: Compare the weighted and the unweighted outcome, and evaluate the uncertainty.

What are unadjusted results?

An unadjusted finding is the bivariate relationship between an independent and dependent variable that does not control for covariates or confounders, such as the relationship between intervention type and adherence.

What is an unadjusted estimate?

When a regression reports an unadjusted estimate, it’s just a regression of X on Y with no other covariates. An adjusted estimate is the same regression of X on Y in the presence of at least one covariate.

What is an adjusted mean?

What Is an Adjusted Mean? The adjusted mean arises when statistical averages must be corrected to compensate for data imbalances and large variances. … An adjusted mean can be determined by removing these outlier figures through regression analysis. Adjusted means are also called least-squares means.

What is the race White Earth?

Created in 1867 by a treaty between the United States and the Mississippi Band of Chippewa Indians, it is one of seven Chippewa reservations in Minnesota. Although the White Earth Chippewa no longer live as their ancestors did, they have kept alive their tribal heritage.

Are Ojibwe and Chippewa the same?

Ojibwa, also spelled Ojibwe or Ojibway, also called Chippewa, self-name Anishinaabe, Algonquian-speaking North American Indian tribe who lived in what are now Ontario and Manitoba, Can., and Minnesota and North Dakota, U.S., from Lake Huron westward onto the Plains.

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What does the name Minnesota mean?

Indeed, Minnesota received its name from the Dakota (Sioux) word for the Mississippi’s major tributary in the state, the Minnesota River, which means Sky-Tinted Water.

What native people lived in Minneapolis?

The native community of Minneapolis is comprised of many nations, the largest being the Dakhta (Dakota), whose cultural history begins at the confluence of the Minnesota and Mississippi Rivers, a sacred place they call Bdte, and the Anishinaabeg (Ojibwe), whose homelands extend northward from the city.

What Native Americans lived in Minneapolis?

By the 1600s there were two main groups of people living in present-day Minnesota, the Dakota and the Ojibwe (also known as Chippewa, Ojibway, or Ojibwa). By the end of the 1600s Europeans had arrived in the region and began a long and complex relationship with American Indians.

How many native tribes are in Minnesota?

11 There are 11 federally recognized American Indian tribes with reservations throughout Minnesota. Seven of these are Anishinaabe (Chippewa, Ojibwe) and four are Dakota (Sioux).

What is Minnesota known for?

Minnesota is known for its lakes and forests, but it’s also home to the Twin Cities: Saint Paul and Minneapolis. The Twin Cities are home to many Fortune 500 companies, including Best Buy, General Mills, Target, and Land ‘o Lakes. The Mall of America in Bloomington, Minnesota is the largest mall in the United States.

Where do Native Americans live in Minnesota?

The White Earth Reservation is located in the northwestern Minnesota counties of Mahnomen, Becker, and Clearwater. The reservation is located 68 miles from Fargo and 225 miles from Minneapolis/St. Paul. Tribal headquarters are in White Earth, Minnesota.

Where is the Anishinaabe reservation?

The reservation includes all of Mahnomen County, plus parts of Becker and Clearwater counties in the northwest part of the state along the Wild Rice and White Earth rivers. It is about 225 miles (362 km) from MinneapolisSaint Paul and roughly 65 miles (105 km) from FargoMoorhead.